A linear graph for digoxin radioimmunoassay.
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چکیده
منابع مشابه
A linear graph for digoxin radioimmunoassay.
The determination of drug or hormone concentrations by radioimmunoassay involves interpolation of values for radioisotope counts within standard curves, a technique which requires some dexterity in curve drawing and which results in some inaccuracy in practice. A number of linear transformations (Ekins, 1974) and computer programs (Burger et al, 1972; Duddleson et al, 1972; Livesey, 1974) for s...
متن کاملMeasurement of digoxin by radioimmunoassay.
A sensitive, specific and precise procedure for the measurement of digoxin by radioimmunoassay is presented. The method is rapid, convenient and highly reliable for this very important measurement. Studies designed to evaluate the validity and reproducibility of the assay are presented and discussed.
متن کاملRadioimmunoassay of serum digoxin in relation to digoxin intoxication.
Serum digoxin estimations were done in 98 patients receiving digoxin for heart failure of varied aetiology. Digoxin toxicity or the lack of it was determined on the basin of established electrocardiographic criteria. Fifty-two patients were classified as 'toxic' and 46 as 'non-toxic'. The difference is the mean digoxin levels between the two groups was highly significant (P less than 0.001). Th...
متن کاملSome factors affecting a commercial kit for radioimmunoassay of digoxin using tritiated digoxin.
Some factors affecting results of digoxin determinations using one commercially available radioimmunoassay kit are described and discussed. Serum of pregnant women, cord blood, amniotic fluid and serum of patients taking spironolactone may show erroneously high digoxin activity due to lack of specificity of the antiserum. Cross-reaction with digitoxin was found to vary substantially with antibo...
متن کاملPostmortem assay of digoxin by radioimmunoassay.
Analysis of postmortem blood samples from patients previously on maintenance digoxin therapy suggests that the results are of value in assessing the degree of digitalization at the time of death. Control cases gave results within the normal therapeutic range wheras of six cases in which digoxin was suspected of being implicated in the death five had 'serum' digoxin levels above the therapeutic ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1975
ISSN: 0021-9746
DOI: 10.1136/jcp.28.10.840